Membrane-Associated Non-Receptors and Morphogen Gradients
نویسندگان
چکیده
منابع مشابه
Membrane-associated non-receptors and morphogen gradients.
A previously investigated basic model (System B) for the study of signaling morphogen gradient formation that allows for reversible binding of morphogens (aka ligands) with signaling receptors, degradation of bound morphogens and diffusion of unbound morphogens is extended to include the effects of membrane-bound non-signaling molecules (or non-receptors for short) such as proteoglycans that bi...
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The importance of morphogens is a central concept in developmental biology. Multiple-fate patterning and the robustness of the morphogen gradient are essential for embryo development. The ways by which morphogens diffuse from a local source to form long distance gradients can differ from one morphogen to the other, and for the same morphogen in different organs. This paper will study the mechan...
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Robust multiple-fate morphogen gradients are essential for embryo development. Here, we analyze mathematically a model of morphogen gradient (such as Dpp in Drosophila wing imaginal disc) formation in the presence of non-receptors with both diffusion of free morphogens and the movement of morphogens bound to non-receptors. Under the assumption of rapid degradation of unbound morphogen, we intro...
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An expansion-repression mechanism by which morphogen gradients can adjust to size and growth had been postulated as a model. Now, its molecular nature has been uncovered.
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Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen gradients. We particularly note the Expansio...
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ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2006
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-006-9152-2